Juvederm Ultra, Restylane, Perlane, Belotero®, Voluma, Sculptra®, Bellafill, and Radiesse® are all Dermal Fillers. They are made of a colorless hyaluronic acid gel that is injected into facial tissue to smooth wrinkles and folds, especially around the nose and mouth. Hyaluronic acid is a naturally occurring sugar chain found in the human body. The role of hyaluronic acid in the skin is to deliver nutrients, hydrate the skin by holding in water, and to act as a cushioning agent. Radiesse contains calcium hydroxylapatite, which is also a naturally occurring biocompatible substance. It lasts longer (9-12 months) than hyaluronic acid and is used in the deep cheeks, under the eye, and temples. Bellafill, a permanent filler, often lasts 5-7 years. It adds volume to facial tissue and restores a smoother appearance. Many patients need at least one treatment of filler (though some may need two or more) to achieve optimal wrinkle smoothing. The results last about 6 months, except Belotero, which lasts 4 months in fine, shallow wrinkles. The filler Sculptra is also considered a collagen stimulator.